Microorganisms and antibiotic resistance in bacterial keratitis at an rural county hospital in Seville

García-Bernal A

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Purpose: Review the incidence, spread, resistance patterns, and management of bacterial keratitis inthe South of Seville in the last 4 years.

Methods: Clinical record results of the microbiological isolates of patients with a clinical diagnosis of bacterial keratitis were retrospectively reviewed.

Results: A total of 159 patients were treated, with 129 cultures. We obtained positive cultures in 76 of 129 cultures (47,2%) and 102 microorganisms (20 cultures had a polymicrobial result). The distribution was 23,7% gram positive, 60,8% gram negative, and 15,5% fungal. The most common were Pseudomona aeruginosa (16,6%), Serratia marcescens (11,7%), and Staphylococcus aureus (9,8%). When analyzing susceptibilities to gram-positive’s bacteria, greater resistance rate was demonstrated for fluoroquinolones (13,6%) and aminoglycosides (18,2%). We observed 10% aminoglycoside resistance in the gram-negative group and 5% resistance to ceftazidime. No resistance to vancomycin was observed.

Conclusions: The higher resistance rate to aminoglycosides and fluoroquinolones in gram-positive’s bacteria in our area differed from the literature, especially inside the Streptococcus group. We propose not using fluoroquinolone, aminoglycoside, or cephalosporin as initial monotherapy management of severe bacterial keratitis in our area.

Key Words

bacteria, antibiotic, keratitis, susceptibility, resistance

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García-Bernal A


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